Endocrine Abstracts

Background: Carbohydrate-restricted diets in type 1 diabetes mellitus (T1DM) are highly controversial. A commonly held concern is that a low carbohydrate diet may more readily result in conversion to diabetic ketoacidosis – one of the most severe complications of poorly managed T1DM. Of note, there is no clear evidence for this phenomenon. We evaluated metabolic profiles in patients with T1DM who had self-selected carbohydrate-restricted diets.<p clas...

Introduction: Chronic kidney disease (CKD) is characterised by an ongoing reduction in kidney function and is associated with comorbidities such as muscle wasting that greatly increase mortality. Both acidosis and elevated glucocorticoids levels are hallmarks of CKD and implicated as having a synergistic role in driving muscle wasting. We investigated the synergistic effects of acidosis and the glucocorticoid cortisol on muscle metabolism and fibre size using ...

Introduction: In recent years there has been a highlight on the inequity of diabetes care and results across the UK. Research needs to be taken into barriers of access to technology for type 1 diabetes in CYP in the UK, specifically looking at provider bias, systemic issues within the health system, and individual and family factors.Aim of the study: We explored the potential factors that might affect access to technolog...

Background: Metastases to the sellar region are extremely rare tumours in surgical series. The reported incidence has recently increased with advances in neuroimaging. Survival of patients with metastatic cancer has improved due to progress in oncologic therapies and diagnostics. Patients with sellar metastases (SM) follow a variable disease course that is not well defined.Objective: The objective was to evaluate the clinical characteristics, surgical ap...

Background: Posterior pituitary tumors (PPTs) present as clinically nonfunctioning space-occupying lesions of the sellar region. The diagnosis of PPTs is not possible on the basis of their clinical, radiological and biochemical features. Immunohistochemistry identifies them for their expression of TTF. They are virtually always mistakenly defined as one of the more common pituitary tumours. Due to their rarity, the long-term endocrine aspects and outcomes of PPTs are not well ...

Introduction: Diffuse sclerosing osteomyelitis (DSO) of the jaw is a chronic and rare condition that can present with recurrent and severe jaw pain and mandibular swelling. The treatment of this condition can often be quite challenging. We present a patient with mandibular DSO who had significant improvement in jaw pain with denosumab injections. Clinical Case: A 23-year-old female presented with left mandible pain for 4 years. Her symptoms started after...

Eneboparatide (AZP-3601) is a novel, synthetic, 36-amino-acid peptide agonist of the parathyroid hormone type 1 receptor (PTHR1), with potent selectivity for the R0 conformation. This results in prolonged calcemic responses, while having a short circulating half-life. Eneboparatide is being developed for the treatment of chronic hypoparathyroidism (cHP). Studies in hypoparathyroid animal models and, most recently, in hypoparathyroid patients, have demonstrated that eneboparati...

Background: Glucocorticoids are powerful anti-infla mmatory drugs. However, metabolic side effects are common and limit their long-term use. Furthermore, the underlying mechanisms of adverSemetabolic effects are not well known, and this lack of knowledge results in poor treatment. We have previously shown that the antidiabetic drug metformin prevents glucocorticoid-induced metabolic effects in older, sick patients. Here, we investigate metformin in a young and healthy populati...

In developed countries, prostate cancer (PCa) is the most prevalent cancer and the second most common cause of cancer related death in males. Tumors from patients exhibiting disease progression after systemic androgen deprivation treatment (ADT), referred to as castration resistant prostate cancer (CRPC), often show differentiation towards an aggressive phenotype – neuroendocrine prostate cancer or NE-PC. In our study, we used the Simian-Virus 40 (SV-40) T-antigen driven ...

Congenital hypogonadotropic hypogonadism (CHH (MIM161110)) due to GnRH deficiency is a rare genetic disorder (affects ~1/30 000) characterised by abnormal pubertal development and infertility. Over 60% cases have anosmia (Kallmann syndrome) and some exhibit additional phenotypes. CHH is a genetically heterogeneous developmental disease. Most cases present sporadically, although familial forms (AD, AR, and X-linked) with incomplete penetrance and variable expressivity occur. Re...